October 4 NFL Betting: 14 Powerful Week 4 Matchups
October 4 Nfl Betting Delivers A 14-Game Sunday Slate From London Through Sunday Night Football.
October 4 NFL Betting delivers one of the deepest Sunday boards of the young season, with 14 games stretching from a 9:30 AM ET London kickoff through Sunday Night Football. Quarterback injuries, major skill-position absences and several tight spreads make shopping for the best number especially important today.
Before placing a wager, compare the market. A half-point can be the difference between cashing and pushing — or winning and losing.
Market snapshot checked October 4. Odds can move before kickoff.
Time ET
Matchup
Spread
Moneyline
Total
9:30 AM
Colts @ Commanders
IND -3.5
IND -180 / WAS +150
47.5
1:00 PM
Patriots @ Bills
BUF -7
NE +240 / BUF -298
48.5
1:00 PM
Jets @ Bears
CHI -3.5
NYJ +145 / CHI -175
42.5
1:00 PM
Jaguars @ Bengals
CIN -2.5
JAX +120 / CIN -142
51.5
1:00 PM
Cardinals @ Giants
ARI -1.5
ARI -115 / NYG -105
44.5
1:00 PM
Rams @ Eagles
LAR -3
LAR -155 / PHI +130
45.5
1:00 PM
Packers @ Buccaneers
GB -3.5
GB -172 / TB +150
39.5
1:00 PM
Titans @ Ravens
BAL -11.5
TEN +525 / BAL -750
43.5
1:00 PM
Cowboys @ Texans
HOU -2.5
DAL +120 / HOU -142
47.5
4:05 PM
Dolphins @ Vikings
MIN -11.5
MIA +525 / MIN -750
38.5
4:25 PM
Chiefs @ Raiders
KC -4.5
KC -225 / LV +185
47.5
4:25 PM
Broncos @ 49ers
SF -3
DEN +130 / SF -155
46.5
4:25 PM
Chargers @ Seahawks
SEA -7
LAC +280 / SEA -335
42.5
8:20 PM
Lions @ Panthers
DET -3.5
DET -175 / CAR +145
50.5
The latest CBS market board confirms the full 14-game Sunday schedule and these morning prices.
NFL Betting Scoreboard
Matchup
Pregame Score
Status
Colts @ Commanders
0-0
9:30 AM ET
Patriots @ Bills
0-0
1:00 PM ET
Jets @ Bears
0-0
1:00 PM ET
Jaguars @ Bengals
0-0
1:00 PM ET
Cardinals @ Giants
0-0
1:00 PM ET
Rams @ Eagles
0-0
1:00 PM ET
Packers @ Buccaneers
0-0
1:00 PM ET
Titans @ Ravens
0-0
1:00 PM ET
Cowboys @ Texans
0-0
1:00 PM ET
Dolphins @ Vikings
0-0
4:05 PM ET
Chiefs @ Raiders
0-0
4:25 PM ET
Broncos @ 49ers
0-0
4:25 PM ET
Chargers @ Seahawks
0-0
4:25 PM ET
Lions @ Panthers
0-0
8:20 PM ET
October 4 NFL Schedule
Sunday begins in London and doesn’t stop until the Lions and Panthers close the night in Charlotte.
Time ET
Game
9:30 AM
Indianapolis Colts @ Washington Commanders — London
1:00 PM
New England Patriots @ Buffalo Bills
1:00 PM
New York Jets @ Chicago Bears
1:00 PM
Jacksonville Jaguars @ Cincinnati Bengals
1:00 PM
Arizona Cardinals @ New York Giants
1:00 PM
Los Angeles Rams @ Philadelphia Eagles
1:00 PM
Green Bay Packers @ Tampa Bay Buccaneers
1:00 PM
Tennessee Titans @ Baltimore Ravens
1:00 PM
Dallas Cowboys @ Houston Texans
4:05 PM
Miami Dolphins @ Minnesota Vikings
4:25 PM
Kansas City Chiefs @ Las Vegas Raiders
4:25 PM
Denver Broncos @ San Francisco 49ers
4:25 PM
Los Angeles Chargers @ Seattle Seahawks
8:20 PM
Detroit Lions @ Carolina Panthers
October 4 NFL Betting Starts Early in London
Indianapolis Colts vs. Washington Commanders — 9:30 AM ET
October 4 NFL Betting begins several hours before the normal Sunday window when Indianapolis and Washington meet at Tottenham Hotspur Stadium.
The biggest handicap is Washington’s quarterback situation. Jayden Daniels is OUT with a left elbow injury, leaving the Commanders without their starting quarterback. Washington is also missing running back Rachaad White, guard Samuel Cosmi and safety Nick Cross, while Terry McLaurin entered the weekend questionable with a hamstring injury.
Indianapolis is not healthy either. Keenan Allen is OUT with a groin injury.
Those absences help explain why Indianapolis is laying points despite both teams entering at 1-2.
Market: Colts -3.5 | Commanders +3.5 | O/U 47.5
Betting angle: Washington’s quarterback downgrade makes the Commanders’ offensive efficiency the central question. Bettors taking Indianapolis should still be careful about laying an inflated number after injury-driven movement.
Eight Games Hit the 1 PM ET Window
Patriots vs. Bills
Buffalo enters the game unbeaten and carries one of Sunday’s larger favorites at -7.
New England’s defensive injury list deserves attention. Christian Barmore and Christian Gonzalez are among the Patriots ruled out, while Buffalo has a much shorter list of major designations.
Line: Bills -7
Total: 48.5
Buffalo’s ability to create separation is the main October 4 NFL Betting question here. New England getting a full touchdown offers obvious underdog appeal, but its defensive absences make containing Buffalo substantially harder.
Jets vs. Bears
This matchup has one of Sunday’s most important quarterback injuries.
Caleb Williams is OUT with a hamstring injury. Chicago also has several defensive and offensive-line absences.
The Jets will be without Breece Hall, Adonai Mitchell and Mason Taylor.
Line: Bears -3.5
Total: 42.5
With significant offensive personnel missing on both sides, this is a game where bettors should look beyond team names and examine how the absences affect pace, rushing efficiency and red-zone production.
Jaguars vs. Bengals
Cincinnati is only a small home favorite, and the 51.5 total is one of the highest numbers on Sunday’s board.
Jacksonville enters 2-1, while Cincinnati is also 2-1.
Line: Bengals -2.5
Total: 51.5
The market is clearly expecting points. When handicapping October 4 NFL Betting totals, however, bettors should compare offensive expectations against the number rather than automatically chasing a projected shootout.
Cardinals vs. Giants
Arizona is a narrow road favorite in one of Sunday’s closest markets.
The Giants entered the final injury report without a game-status designation, while Arizona ruled out safety Dadrion Taylor-Demerson and listed Josh Sweat questionable.
Line: Cardinals -1.5
Total: 44.5
With essentially a field-goal-or-less spread, moneyline bettors may find this matchup more attractive than paying spread juice.
Rams vs. Eagles
This may be the most injury-sensitive game in the early window.
Los Angeles is without Aaron Donald, while Philadelphia has ruled out DeVonta Smith, Marquise Brown and Dallas Goedert, along with Zack Baun and other contributors.
Line: Rams -3
Total: 45.5
Philadelphia’s missing pass catchers create an obvious challenge. The question for bettors is whether the market has already adjusted enough.
October 4 NFL Betting is loaded with injury-created price changes, and Rams-Eagles is one of the clearest examples.
Packers vs. Buccaneers
Tampa Bay faces the most important injury possible: Baker Mayfield is OUT with a right thumb injury.
That quarterback news is central to Green Bay being favored on the road.
Line: Packers -3.5
Total: 39.5
A total below 40 immediately tells bettors how the market views Tampa Bay’s offensive outlook without Mayfield.
Green Bay has injury concerns of its own along the offensive line, so laying points on the road is not automatically comfortable.
Titans vs. Ravens
Baltimore owns the biggest spread of Sunday’s early games.
Line: Ravens -11.5
Total: 43.5
Tennessee enters 0-3, while Baltimore is 2-1.
The Ravens are missing Trey Hendrickson and two centers, while Zay Flowers is among Baltimore’s questionable players.
Double-digit NFL spreads demand discipline. Baltimore may be the substantially stronger team, but bettors must decide whether winning comfortably and covering 11.5 points are the same proposition.
Cowboys vs. Texans
Houston is searching for its first victory but remains favored over Dallas.
Line: Texans -2.5
Total: 47.5
Dallas is missing linebacker DeMarvion Overshown and corner Cobie Durant. Houston has ruled out Azeez Al-Shaair and M.J. Stewart, with several other defenders questionable.
This is exactly the type of October 4 NFL Betting matchup where public perception and actual price can diverge.
Minnesota is one of Sunday’s largest favorites at -11.5, but the Vikings have a major offensive absence of their own.
Justin Jefferson is OUT with an ankle injury.
Miami enters 0-3, while Minnesota enters 3-0.
Line: Vikings -11.5
Total: 38.5
The Jefferson absence matters when laying nearly two touchdowns. Minnesota may control the matchup, but covering a large spread requires offensive margin.
Chiefs vs. Raiders — 4:25 PM ET
This AFC West game carries one of Sunday’s more interesting records: both Kansas City and Las Vegas enter 3-0.
Line: Chiefs -4.5
Total: 47.5
Kansas City will be without left tackle Josh Simmons, while Las Vegas has ruled out Jackson Powers-Johnson.
The Chiefs are still favored on the road, but an unbeaten Raiders team catching more than a field goal creates one of the most interesting price-versus-record debates on the October 4 NFL Betting board.
Broncos vs. 49ers — 4:25 PM ET
San Francisco enters 3-0 and is laying a field goal against Denver.
Line: 49ers -3
Total: 46.5
The 49ers’ injury report matters. Nick Bosa and Mykel Williams are OUT, while Mike Evans is among the questionable players.
Denver enters 2-1, making this far from a routine home-favorite spot.
Chargers vs. Seahawks — 4:25 PM ET
Seattle is a touchdown favorite at home.
Line: Seahawks -7
Total: 42.5
Los Angeles has a lengthy injury list. Ladd McConkey, Derwin James and several other Chargers entered the weekend questionable, while multiple teammates were already ruled out.
Seattle’s home-field environment plus the Chargers’ health concerns explain the substantial spread.
Sunday Night Football: Lions vs. Panthers
October 4 NFL Betting concludes at 8:20 PM ET when Detroit visits Carolina.
Line: Lions -3.5
Moneyline: Lions -175 / Panthers +145
Total: 50.5
Detroit enters 2-1 while Carolina is 1-2.
The Panthers will be without Xavier Legette and guard Damien Lewis. Several additional Carolina players are questionable.
This game also owns one of Sunday’s highest totals, setting up a potentially aggressive Sunday Night Football market.
Carolina getting more than a field goal at home will attract underdog bettors. Detroit backers, meanwhile, have to determine whether the Lions’ offensive ceiling justifies laying points on the road.
Biggest October 4 NFL Betting Injury Factors
The injury report should be part of every handicap today.
The most important confirmed absences include:
Commanders QB Jayden Daniels — OUT
Colts WR Keenan Allen — OUT
Jets RB Breece Hall — OUT
Bears QB Caleb Williams — OUT
Eagles WR DeVonta Smith — OUT
Eagles TE Dallas Goedert — OUT
Eagles WR Marquise Brown — OUT
Buccaneers QB Baker Mayfield — OUT
Vikings WR Justin Jefferson — OUT
Chiefs LT Josh Simmons — OUT
49ers DE Nick Bosa — OUT
Panthers WR Xavier Legette — OUT
NFL.com’s Week 4 report confirms those major Sunday designations.
Before You Bet: Four Final Checks
1. Check the quarterback.
Daniels, Williams and Mayfield being unavailable can alter spreads, totals and player-prop markets.
2. Check the final inactive list.
Questionable does not mean out. Late confirmations can move a line quickly.
3. Shop multiple sportsbooks.
A -3 instead of -3.5 or +7 instead of +6.5 can determine whether the ticket cashes.
4. Don’t chase the market.
If the number has moved significantly away from the price that created your original edge, reconsider the wager.
October 4 NFL Betting offers nearly 11 straight hours of Sunday football, but the size of the board is exactly why bettors need discipline.
The Colts and Commanders open the action in London. Eight games crowd the 1:00 PM ET window. Minnesota, Kansas City, San Francisco and Seattle headline the late afternoon before Detroit and Carolina finish the night.
More importantly, major injuries have already changed several matchups.
Don’t bet yesterday’s perception against today’s lineup.
Check the injuries. Compare the numbers. Know the price you are willing to play — and walk away when the market no longer gives you an edge.
Stay disciplined. Find the edge. Cash tickets.
— TheSportsDoc11 | HandicappersHideaway.com
